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Introduction

M D NAIROur lifestyle today exposes us to several stresses, which take their toll on the body, especially the joints. Osteoarthritis, rheumatoid arthritis and osteoporosis are becoming more widespread in society today, which in turn lead to further psychosomatic complications.

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Mechanism of Action

Collagen Peptide is a mixture of easily absorbable tri, di-peptides and amino acids. The amino acid composition of collagen peptide and that of collagen in articular cartilage are almost similar. Collagen Peptide contains Glycine, Proline and Hydroxyproline about 3 times compared to proteins from other sources. Preclinical and cell cultural studies shows that food derived collagen peptides are absorbed as di-peptides and amino acids. These peptides and amino acids stimulate chondrocytes and initiate anabolic phase of chondrocytes metabolism. This implies that peptide derivatives of collagen have a role to play in stimulating the synthesis of extracellular matrix of Chondrocytes and thereby initiate cartilage regeneration.

Clinical Study done India

There have been 18 clinical studies around the world, demonstrating the beneficial effects of collagen peptides on collagen regeneration. In India, a double blind, placebo-controlled, randomized trial was conducted to determine the effectiveness and safety of bovine bone collagen peptide as an add-on nutritional supplement in management of subjects with knee joint osteoarthritis. The trial was conducted by a medical team led by Dr.V.T.Sriraam (M.D. Pharmacology) of Auroville Healthcare.

Conclusion of the study

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Other Research Studies

a. Clinical Studies
  • Significant improvement in WOMAC score (F=12.40, p=0.0001 and VAS Score (F=12.94, p<0.0001) between group from baseline to visit 7, from one to thirteen weeks in BBCP group, which in turn resulted in improvement of overall Quality of Life ( F=15.35, p=0.0001).
  • As the Investigational product is a nutritional supplement it has resulted in best improvements in subjects with grade 2 Osteoarthritis.
  • The present study demonstrated that oral ingestion of Bovine Bone Collagen Peptide is safe and can improve joint function and quality of life in patients with knee joint Osteoarthritis.

Absorption of Collagen Peptide into Blood

  1. Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. Iwai K, Hasegawa T, Taguchi Y, Morimatsu F, Sato K, Nakamura Y, Higashi A, Kido Y, Nakabo Y, Ohtsuki K. J Agric Food Chem 53:6531-6536 (2005).

  2. Ohara, H. Matsumoto, H. Ito K. Iwai, K. Sato, K. (2007). Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J. Agric. Food Chem. 55(4), 1532-1535

Treatment of Osteoarthritis and Joint pain

  1. Role of Collagen Hydrolysate in Bone and Joint Disease. Moskowiz RW. Semin Arth Rheum 30:97-99 (2000).

  2. Fujita, T. Ohue, M. Fujii, Y. Miyauchi, A. Takagi, Y. The effect of absorbable alga calcium(AAA Ca) with collagen and other matrix components on back and joint pain and skin impedance. J. Bone Miner. Metabol., 20, 298-302l

  3. What effects do gelatin preparations have? Therapy of osteoarthritis [in German]. Adam M. Therapiewoche. 1991;41:2456-2461.

  4. Collagen hydrolysate supplementation improve symptoms in patients with severe osteoarthritis .Carpenter MR, Carpenter RL, McCarthy SM, Kline G, Angelopoulos TJ, Rippe JM. Med Sci Sports Exerc. 2005;37(suppl):S91-S92.

  5. On supportive therapy for osteo- and chondropathy [in German]. Krug E. Ernährun- gsheilkunde. 1979;28:1-23.

  6. Well-nourished cartilage does not grind [in German]. Götz B. Ärztliche Praxis. 1982;34:3130-3134.

  7. Individual arthrosis therapy is possible U. Oberschelp

  8. Can a mixture of gelatin and L-cystine stimulate proteoglycan synthesis? [in German]. Seeligmüller K, Happel HK. Therapiewoche. 1989;39:3153-3157.

  9. Can a mixture of gelatin and L-cystine stimulate proteoglycan synthesis? [in German]. Seeligmüller K, Happel HK. Therapiewoche. 1993

  10. Biochemical and clinical examinations on the effects of regular applications of gelatine on degenerative damages of the motoric system [abstract]. Beuker F, Eck T, Rosenfeld J. Int J Sports Med. 1996;17(suppl 1):S67-S70.

  11. Effects of gelatine hydrolysates in the prevention of athletic injuries. Fernández JL, Pérez OM. Archivos de Medicina del Deporte. 1998;15:277-282.

  12. b. Pre - Clinical Studies
    1. Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL) Steffen Oesser,1 Milan Adam, Wilfried Babel and Jurgen Seifert Surgical Research of the Department of General Surgery and Thoracic Surgery of the University of Kiel, Germany

    2. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen Steffen Oesser, Jurgen Seifert, Cell Tissue Res (2003) 311:393–399 DOI 10.1007/s00441-003-0702-8 REGULAR ARTICLE

    3. Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo, S.Nakatani, H. Mano, C. Sampei, J.Shimzu, M.Wada, Published by Elsevier Ltd. on behalf of Osteoarthritis Research Society International.

    4. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats Jian Wu, Maiko Fujioka, Kiho Sugimoto,Gang Mu and Yoshiko Ishimi Division of Applied Food Research, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan Journal of Bone and Mineral Metabolism Volume 22, Number 6 / November, 2004



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